Article
Differential effects of P-glycoprotein inhibitors on NIH3T3 cells transfected with wild-type (G185) or mutant (V185) multidrug transporters.
Cancer research - 1 Mar 1995
Cardarelli C O, Aksentijevich I, Pastan I, Gottesman M M
Abstract excerpt
Multidrug resistance (MDR) may be associated with the expression of the MDR1 gene which encodes the 170-kDa cell surface P-glycoprotein (PGP) acting as an energy-dependent multidrug efflux pump. This pump can be inhibited by a variety of drugs including cyclosporin A, quinidine, and verapamil. Substrate specificity of the MDR1 gene product can be altered by a point mutation at amino acid residue 185 in which...
Topics
- 3T3 Cells
- ATP Binding Cassette Transporter, Subfamily B, Member 1
- Animals
- Antineoplastic Agents
- Biological Transport, Active
- Carrier Proteins
- Cell Death
- Cell Survival
- Colchicine
- Cyclosporine