Article
Peptide transport by the multidrug resistance pump.
The Journal of biological chemistry - 25 Mar 1992
Sharma R C, Inoue S, Roitelman J, Schimke R T, Simoni R D
Abstract excerpt
The membrane P-glycoprotein (P170) is an ATP-hydrolyzing transmembrane pump, and elevated levels of P170, due to higher expression with or without amplification of the multidrug resistance gene (mdr1), result in resistance to a variety of chemotherapeutic agents in mammalian cells. The function o...
Topics
- 3T3 Cells
- ATP Binding Cassette Transporter, Subfamily B, Member 1
- Animals
- CHO Cells
- Cell Survival
- Cricetinae
- Drug Resistance
- Escherichia coli
- Kinetics
- Leupeptins
- Membrane Glycoproteins
- Mice
- Phenotype
- Protease Inhibitors