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Article

Peptide transport by the multidrug resistance pump.

The Journal of biological chemistry - 25 Mar 1992

Sharma R C, Inoue S, Roitelman J, Schimke R T, Simoni R D

Abstract excerpt

The membrane P-glycoprotein (P170) is an ATP-hydrolyzing transmembrane pump, and elevated levels of P170, due to higher expression with or without amplification of the multidrug resistance gene (mdr1), result in resistance to a variety of chemotherapeutic agents in mammalian cells. The function of the P170 pump has been proposed as a protection against toxic substances present in animal diets. Here we describe a...

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PMID: 1348245

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