Probing the interaction of the multidrug-resistance phenotype with the polypeptide ionophore gramicidin D via functional channel formation.

doi:10.1111/j.1432-1033.1994.tb18928.x

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Article

Probing the interaction of the multidrug-resistance phenotype with the polypeptide ionophore gramicidin D via functional channel formation.

European journal of biochemistry - 15 Jun 1994

Assaraf Y G, Borgnia M J

Abstract excerpt

It has been proposed that the multidrug resistance (MDR) transporter, P-glycoprotein (P-170), may be physiologically involved in the transport of polypeptides. As a step towards understanding the interaction of P-170 with polypeptides, we isolated various gramicidin-D-resistant mammalian cell lines. Gramicidin D is a hydrophobic pentadecapeptide ionophore that forms proton and alkali metal cation-permeable...

Topics

ATP Binding Cassette Transporter, Subfamily B, Member 1
Animals
Antineoplastic Agents
CHO Cells
Carrier Proteins
Cell Line
Cricetinae
Cricetulus
Daunorubicin
Drug Resistance
Flow Cytometry

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Gene Amplification

Gramicidin

Ion Channels

Ionophores

Membrane Glycoproteins

Phenotype

Rhodamine 123

Source

Open in PubMed

Identifiers

PMID: 7517866
DOI: 10.1111/j.1432-1033.1994.tb18928.x

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-7517866-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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