Article
[Expression of P-glycoprotein 170 (GP 170) and drug resistance in human cancers].
Bulletin du cancer - 1 Jan 1990
Bourhis J, Riou G, Bénard J
Abstract excerpt
In vitro models with multiple drug resistance (MDR) phenotype have been frequently related to hyperproduction of the 170 kd membrane glycoprotein, the so-called 170 GP. This protein is a pump able to extrude from cytoplasm drugs with various structures and mechanisms such as doxorubicin (DXR) or vinblastin (VLB). The MDR1 gene encodes the GP 170. MDR1 gene expression is low in most of the normal tissues, but high...
Topics
- ATP Binding Cassette Transporter, Subfamily B, Member 1
- Drug Resistance
- Female
- Gene Expression
- Humans
- Male
- Membrane Glycoproteins
- Neoplasm Proteins
- Neoplasms
- Phenotype