Transfer of adriamycin resistance by fusion of Mr 170,000 P-glycoprotein to the plasma membrane of sensitive cells.

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Article

Transfer of adriamycin resistance by fusion of Mr 170,000 P-glycoprotein to the plasma membrane of sensitive cells.

Cancer research - 1 Apr 1990

Belli J A, Zhang Y, Fritz P

Abstract excerpt

One of the characteristics of multidrug-resistant mammalian cells is the presence of a glycoprotein of approximately Mr 170,000 in their cell membrane. Termed P-glycoprotein, this glycoprotein is thought to be the gene product of an amplified gene cloned and sequenced from a cell line (LZ) which...

Topics

ATP Binding Cassette Transporter, Subfamily B, Member 1
Animals
Biological Transport
Blotting, Western
Cell Line
Cell Membrane
Cricetinae
Doxorubicin
Drug Resistance
Immunoenzyme Techniques
Membrane Glycoproteins
Molecular Weight
Phenotype

Source

Open in PubMed

Identifiers

PMID: 1969329

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-1969329-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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