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The effects of prolonged treatment with zidovudine, lamivudine, and abacavir on a T-lymphoblastoid cell line.

AIDS research and human retroviruses - 1 Oct 2006

Turriziani Ombretta, Pagnotti Paolo, Pierangeli Alessandra, Focher Federico, Baranello Cinzia, Bellomi Francesca, Falasca Francesca, Morgan Jessica, Schuetz John D, Antonelli Guido

Abstract excerpt

A human T-lymphoblastoid cell line that is resistant to the antiviral activity of zidovudine (ZDV) and moderately resistant to lamivudine (3TC) has been obtained as a result of prolonged treatment with a combination of three nucleoside analogues (NA), ZDV, 3TC, and abacavir (ABV). These cells, called CEM(ZLA), are fully sensitive to ABV. The cellular resistance of the CEM(ZLA) cells to ZDV correlates with...

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PMID: 17067265
DOI: 10.1089/aid.2006.22.960

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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