Characterization of Chinese hamster ovary cells that are resistant to 3-beta-[2-(diethylamino)ethoxy]androst-5-en-17-one inhibition of low density lipoprotein-derived cholesterol metabolism.

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Article

Characterization of Chinese hamster ovary cells that are resistant to 3-beta-[2-(diethylamino)ethoxy]androst-5-en-17-one inhibition of low density lipoprotein-derived cholesterol metabolism.

The Journal of biological chemistry - 5 Sept 1991

Liscum L, Collins G J

Abstract excerpt

The pharmacological agent U18666A (3-beta-[2-(diethylamino)ethoxy]androst-5-en-17-one inhibits the intracellular transport of low density lipoprotein (LDL)-derived cholesterol in Chinese hamster ovary (CHO) cells. LDL-derived cholesterol accumulates in the lysosomes of U18666A-treated cells causing delayed LDL-mediated regulation of cellular cholesterol metabolism and impaired movement of LDL-derived cholesterol...

Topics

Androstenes
Animals
Anticholesteremic Agents
Biological Transport
Cell Division
Cell Line
Cell Membrane
Cholesterol, LDL
Colchicine
Cricetinae
Daunorubicin

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Drug Resistance

Esterification

Hydroxymethylglutaryl CoA Reductases

Ketoconazole

Kinetics

Phenotype

Receptors, LDL

Source

Open in PubMed

Identifiers

PMID: 1885589

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-1885589-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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