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Article

Diversity of multidrug resistance in mammalian cells.

The Journal of biological chemistry - 25 Feb 1994

Devine S E, Melera P W

Abstract excerpt

Mammalian cells displaying the multidrug resistance (mdr) phenotype are refractory to the toxic effects of a group of unrelated natural product drugs, many of which are used for cancer chemotherapy. The pattern of cross-resistance can be extremely variable among independently selected cell lines, even though such cells are often exposed to only a single drug. The overexpression of P-glycoprotein (pgp), a...

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PMID: 7907088

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