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Article

P-glycoprotein overexpression in methotrexate-resistant Leishmania tropica.

Biochemical pharmacology - 1 Jun 1994

Gamarro F, Chiquero M J, Amador M V, Légaré D, Ouellette M, Castanys S

Abstract excerpt

A methotrexate (MTX)-resistant Leishmania tropica line develops a stable drug-resistant phenotype in which the resistance mechanism is associated with a significant reduction in MTX accumulation. After a 2 hr exposure to [3H]MTX, a L. tropica line resistant to 1000 microM of MTX did not accumulate more than 3% of the amount of drug incorporated by wild-type cells. The same resistant cell line was found to be...

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PMID: 7912069
DOI: 10.1016/0006-2952(94)90067-1

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