Article
P-glycoprotein overexpression in methotrexate-resistant Leishmania tropica.
Biochemical pharmacology - 1 Jun 1994
Gamarro F, Chiquero M J, Amador M V, Légaré D, Ouellette M, Castanys S
Abstract excerpt
A methotrexate (MTX)-resistant Leishmania tropica line develops a stable drug-resistant phenotype in which the resistance mechanism is associated with a significant reduction in MTX accumulation. After a 2 hr exposure to [3H]MTX, a L. tropica line resistant to 1000 microM of MTX did not accumulat...
Topics
- ATP Binding Cassette Transporter, Subfamily B, Member 1
- Animals
- Carrier Proteins
- Cell Line
- Drug Resistance
- Gene Expression
- Leishmania tropica
- Membrane Glycoproteins
- Methotrexate
- Phenotype