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Article

Development of mature CD8+ thymocytes: selection rather than instruction?

Science (New York, N.Y.) - 13 Aug 1993

van Meerwijk J P, Germain R N

Abstract excerpt

The role of major histocompatibility complex (MHC) molecules in T cell differentiation was investigated by comparison of thymocyte subpopulations in wild-type mice and beta 2-microglobulin (beta 2M) mutant mice deficient in MHC class I expression and mature CD8+ cells. On the basis of surface markers, glucocorticoid resistance, in vitro differentiation capacity, and absence in beta 2 M-l- mice,...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 8102208
DOI: 10.1126/science.8102208

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

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Development of mature CD8+ thymocytes: selection rather than instruction?PMID 8102208Read ↗

Thymocytes can become mature T cells without passing through the CD4+ CD8+, double-positive stage.Semantic proximity Read ↗

Phenotypic and functional analysis of positive selection in the gamma/delta T cell lineage.Semantic proximity Read ↗

Beta 2-microglobulin deficient mice lack CD4-8+ cytolytic T cells.Semantic proximity Read ↗

Analyses of the TCR repertoire of MHC class II-restricted innate CD4⁺ T cells.Semantic proximity Read ↗

Phenotypic changes accompanying positive selection of CD4+CD8+ thymocytes.Semantic proximity Read ↗

Evidence for lineage commitment and initiation of positive selection by thymocytes with intermediate surface phenotypes.Semantic proximity Read ↗

Normal development of mice deficient in beta 2M, MHC class I proteins, and CD8+ T cells.Semantic proximity Read ↗

Visualization of CD4/CD8 T cell commitment.Semantic proximity Read ↗

Disruption of hypothalamic-pituitary-adrenocortical system in transgenic mice expressing type II glucocorticoid receptor antisense ribonucleic acid permanently impairs T cell function: effects on T cell trafficking and T cell responsiveness during postnatal development.Semantic proximity Read ↗

Negative selection of thymocytes expressing the D10 TCR.Semantic proximity Read ↗

Distinct sequence of negative or positive selection implied by thymocyte T-cell receptor densities.Semantic proximity Read ↗

Evidence for programmed cell death of self-reactive gamma delta T cell receptor-positive thymocytes.Semantic proximity Read ↗

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