Article
Development of mature CD8+ thymocytes: selection rather than instruction?
Science (New York, N.Y.) - 13 Aug 1993
van Meerwijk J P, Germain R N
Abstract excerpt
The role of major histocompatibility complex (MHC) molecules in T cell differentiation was investigated by comparison of thymocyte subpopulations in wild-type mice and beta 2-microglobulin (beta 2M) mutant mice deficient in MHC class I expression and mature CD8+ cells. On the basis of surface markers, glucocorticoid resistance, in vitro differentiation capacity, and absence in beta 2 M-l- mice,...
Topics
- Animals
- CD4 Antigens
- CD4-Positive T-Lymphocytes
- CD8 Antigens
- Cell Differentiation
- Dexamethasone
- Histocompatibility Antigens Class I
- Male
- Mice
- Mice, Inbred C57BL
- Phenotype
- Receptors, Antigen, T-Cell, alpha-beta