Article
Analyses of the TCR repertoire of MHC class II-restricted innate CD4⁺ T cells.
Experimental & molecular medicine - 27 Mar 2015
Kang Byung Hyun, Min Hye Sook, Lee You Jeong, Choi Bomi, Kim Eun Ji, Lee Jonghoon, Kim Jeong-Rae, Cho Kwang-Hyun, Kim Tae Jin, Jung Kyeong Cheon, Park Seong Hoe
Abstract excerpt
Analysis of the T-cell receptor (TCR) repertoire of innate CD4(+) T cells selected by major histocompatibility complex (MHC) class II-dependent thymocyte-thymocyte (T-T) interaction (T-T CD4(+) T cells) is essential for predicting the characteristics of the antigens that bind to these T cells and for distinguishing T-T CD4(+) T cells from other types of innate T cells. Using the TCR(mini) Tg mouse model, we show...
Topics
- Amino Acid Sequence
- Animals
- Antigens, Surface
- CD4-Positive T-Lymphocytes
- Cell Communication
- Cell Differentiation
- Clonal Evolution
- Histocompatibility Antigens Class II
- Immunity, Innate
- Immunophenotyping
- Lymphocyte Count
- Mice
- Mice, Knockout