Article
Phenotypic changes accompanying positive selection of CD4+CD8+ thymocytes.
European journal of immunology - 1 Sept 1992
Swat W, Dessing M, Baron A, Kisielow P, von Boehmer H
Abstract excerpt
We know little about the way mature CD4 (helper) and CD8 (killer) T cells develop from thymic CD4+CD8+ precursors. Here we show that small but not large CD4+CD8+ cells with high levels of the alpha beta T cell receptor (TcRhigh) result from positive selection. Neither CD4+CD8+ cells with low TcR...
Topics
- Animals
- CD4 Antigens
- CD8 Antigens
- Cell Differentiation
- Mice
- Mice, Inbred C57BL
- Mice, Inbred DBA
- Phenotype
- Receptors, Antigen, T-Cell
- T-Lymphocytes