Article
Visualization of CD4/CD8 T cell commitment.
The Journal of experimental medicine - 21 Dec 1998
Chan S, Correia-Neves M, Dierich A, Benoist C, Mathis D
Abstract excerpt
A system to innocuously visualize T cell lineage commitment is described. Using a "knock-in" approach, we have generated mice expressing a beta-galactosidase reporter in place of CD4; expression of beta-galactosidase in these animals appears to be an accurate and early indicator of CD4 gene trans...
Topics
- Animals
- Antigens, CD
- CD4-Positive T-Lymphocytes
- CD8-Positive T-Lymphocytes
- Cell Differentiation
- Cell Lineage
- Cells, Cultured
- Down-Regulation
- Genes, Reporter
- Heterozygote
- Histocompatibility Antigens Class I
- Histocompatibility Antigens Class II
- Mice
- Mice, Inbred C57BL
- Mice, Transgenic
- Phenotype
- RNA, Messenger
- Recombination, Genetic