Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Phenotypic and functional analysis of positive selection in the gamma/delta T cell lineage.

The Journal of experimental medicine - 1 Apr 1993

Wells F B, Tatsumi Y, Bluestone J A, Hedrick S M, Allison J P, Matis L A

Abstract excerpt

Recent evidence suggests that T cells expressing gamma/delta antigen receptors (T cell receptor [TCR]) are subject to positive selection during development. We have shown that T cells expressing a class I major histocompatibility complex (MHC)-specific gamma/delta TCR transgene (tg) are not positively selected in class I MHC-deficient, beta 2-microglobulin (beta 2m) gene knockout mice (tg+ beta 2m-). In this...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cell Differentiation
Share to Mice
Share to Mice, Inbred BALB C

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Mice, Inbred C57BL

Share to Mice, Transgenic

Share to Phenotype

Share to Signal Transduction

Share to T-Lymphocytes

Source

Open in PubMed Open full text

Identifiers

PMID: 8459203
DOI: 10.1084/jem.177.4.1061
PMCID: PMC2190965

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Phenotypic and functional analysis of positive selection in the gamma/delta T cell lineage.PMID 8459203Read ↗

Phenotypic changes accompanying positive selection of CD4+CD8+ thymocytes.Semantic proximity Read ↗

Development of T cell receptor-gamma delta cells. Phenotypic and functional correlations of T cell receptor-gamma delta thymocyte maturation.Semantic proximity Read ↗

CD2 regulates the positive selection and function of antigen-specific CD4- CD8+ T cells.Semantic proximity Read ↗

Positive selection of gamma delta T cells.Semantic proximity Read ↗

TCR selection and allelic exclusion in RAG transgenic mice that exhibit abnormal T cell localization in lymph nodes and lymphatics.Semantic proximity Read ↗

Repertoire development and ligand specificity of murine TCR gamma delta cells.Semantic proximity Read ↗

Molecular organization, ontogeny and expression of murine alpha beta and gamma delta T cell receptors.Semantic proximity Read ↗

T cell receptor (TcR) beta chain transgenic mice: studies on allelic exclusion and on the TcR+ gamma/delta population.Semantic proximity Read ↗

Thymic selection can compensate for mutations affecting T cell activation and generate a normal T cell repertoire in mutant mice.Semantic proximity Read ↗

Distinct sequence of negative or positive selection implied by thymocyte T-cell receptor densities.Semantic proximity Read ↗

Evidence for programmed cell death of self-reactive gamma delta T cell receptor-positive thymocytes.Semantic proximity Read ↗

Multiple rearrangements in T cell receptor alpha chain genes maximize the production of useful thymocytes.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.