Beta 2-microglobulin deficient mice lack CD4-8+ cytolytic T cells.

doi:10.1038/344742a0

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Article

Beta 2-microglobulin deficient mice lack CD4-8+ cytolytic T cells.

Nature - 19 Apr 1990

Zijlstra M, Bix M, Simister N E, Loring J M, Raulet D H, Jaenisch R

Abstract excerpt

Mice homozygous for a beta 2-microglobulin gene disruption do not express any detectable beta 2-m protein. They express little if any functional major histocompatibility complex (MHC) class I antigen on the cell surface yet are fertile and apparently healthy. They show a normal distribution of ga...

Topics

Animals
Cytotoxicity, Immunologic
H-2 Antigens
Histocompatibility Antigens Class I
Homozygote
Leukocyte Count
Mice
Mice, Mutant Strains
Mutation
Nucleic Acid Hybridization
RNA, Messenger
Receptors, Antigen, T-Cell
Receptors, Fc
T-Lymphocytes, Cytotoxic
T-Lymphocytes, Helper-Inducer
beta 2-Microglobulin

Source

Open in PubMed

Identifiers

PMID: 2139497
DOI: 10.1038/344742a0

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-2139497-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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