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Article

Beta 2-microglobulin deficient mice lack CD4-8+ cytolytic T cells.

Nature - 19 Apr 1990

Zijlstra M, Bix M, Simister N E, Loring J M, Raulet D H, Jaenisch R

Abstract excerpt

Mice homozygous for a beta 2-microglobulin gene disruption do not express any detectable beta 2-m protein. They express little if any functional major histocompatibility complex (MHC) class I antigen on the cell surface yet are fertile and apparently healthy. They show a normal distribution of gamma delta, CD4+8+ and CD4+8- T cells, but have no mature CD4-8+ T cells and are defective in CD4-8+ T cell-mediated...

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PMID: 2139497
DOI: 10.1038/344742a0

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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