Article
Thymocytes can become mature T cells without passing through the CD4+ CD8+, double-positive stage.
The Journal of experimental medicine - 1 Nov 1996
Liu C P, Kappler J W, Marrack P
Abstract excerpt
T cells bearing the class II-restricted, DO-T cell receptor (TCR) are CD4+ if their thymocyte precursors are positively selected on the class II protein, IAd, but they are almost all CD4- after positive selection on a class II for which they have higher avidity, IAb. DO-TCR+ T cells mature in H-2b mice lacking CD4. CD4- DO-TCR+ T cells appear in H-2b mice at the same rate as their CD4+ counterparts appear in H-2d...
Topics
- Animals
- CD4 Antigens
- CD8 Antigens
- Cell Differentiation
- Chimera
- DNA Methylation
- H-2 Antigens
- Histocompatibility Antigens Class II
- Humans
- Mice
- Mice, Inbred BALB C
- Mice, Inbred C57BL
- Mice, Knockout
- Mice, Transgenic
- Phenotype
- Receptors, Antigen, T-Cell, alpha-beta
- T-Lymphocytes
- Thymus Gland