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Article

Evidence for lineage commitment and initiation of positive selection by thymocytes with intermediate surface phenotypes.

Journal of immunology (Baltimore, Md. : 1950) - 15 Jun 1995

van Meerwijk J P, O'Connell E M, Germain R N

Abstract excerpt

Previous studies have shown that both MHC class I and class II molecules can stimulate CD4+CD8+ thymocytes to develop into TCRint cells with surface phenotypes, suggesting initial differentiation along either the CD4 or CD8 developmental pathways. In accord with the view that these cells have undergone lineage commitment, we show here that CD4intTCRint cells generated by recognition of either MHC class show the...

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PMID: 7759870

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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Evidence for lineage commitment and initiation of positive selection by thymocytes with intermediate surface phenotypes.PMID 7759870Read ↗

Phenotypic changes accompanying positive selection of CD4+CD8+ thymocytes.Semantic proximity Read ↗

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CD8 lineage commitment in the absence of CD8.Semantic proximity Read ↗

Phenotypic comparison of the three populations of human lymphocytes defined by CD45RO and CD45RA expression.Semantic proximity Read ↗

Negative selection of thymocytes expressing the D10 TCR.Semantic proximity Read ↗

Differentiation of CD4(high)CD8(low) coreceptor-skewed thymocytes into mature CD8 single-positive cells independent of MHC class I recognition.Semantic proximity Read ↗

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Posttranslational regulation of TCR Valpha allelic exclusion during T cell differentiation.Semantic proximity Read ↗

CD4-CD8 lineage commitment: an inside view.Semantic proximity Read ↗

Regulation of lineage commitment distinct from positive selection.Semantic proximity Read ↗

Thymocytes can become mature T cells without passing through the CD4+ CD8+, double-positive stage.Semantic proximity Read ↗

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