Article
Evidence for lineage commitment and initiation of positive selection by thymocytes with intermediate surface phenotypes.
Journal of immunology (Baltimore, Md. : 1950) - 15 Jun 1995
van Meerwijk J P, O'Connell E M, Germain R N
Abstract excerpt
Previous studies have shown that both MHC class I and class II molecules can stimulate CD4+CD8+ thymocytes to develop into TCRint cells with surface phenotypes, suggesting initial differentiation along either the CD4 or CD8 developmental pathways. In accord with the view that these cells have und...
Topics
- Animals
- CD4 Antigens
- CD8 Antigens
- Cell Differentiation
- Down-Regulation
- Histocompatibility Antigens Class I
- Histocompatibility Antigens Class II
- Mice
- Mice, Inbred C57BL
- Mice, Mutant Strains
- Models, Biological
- Phenotype
- Receptors, Antigen, T-Cell, alpha-beta
- T-Lymphocytes