Article
Normal development of mice deficient in beta 2M, MHC class I proteins, and CD8+ T cells.
Science (New York, N.Y.) - 8 Jun 1990
Koller B H, Marrack P, Kappler J W, Smithies O
Abstract excerpt
Major histocompatibility class I proteins display viral and self antigens to potentially responsive cells and are important for the maturation of T cells; beta 2-microglobulin (beta 2M) is required for their normal expression. Mouse chimeras derived from embryonic stem cells with a disrupted beta...
Topics
- Animals
- Antigens, Differentiation, T-Lymphocyte
- CD4 Antigens
- CD8 Antigens
- Chimera
- Gene Expression
- Genes
- Genes, MHC Class I
- Histocompatibility Antigens Class I
- Lymph Nodes
- Mice
- Mice, Inbred C57BL
- Mice, Mutant Strains
- Mutation
- Spleen
- T-Lymphocytes
- beta 2-Microglobulin