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Article

Normal development of mice deficient in beta 2M, MHC class I proteins, and CD8+ T cells.

Science (New York, N.Y.) - 8 Jun 1990

Koller B H, Marrack P, Kappler J W, Smithies O

Abstract excerpt

Major histocompatibility class I proteins display viral and self antigens to potentially responsive cells and are important for the maturation of T cells; beta 2-microglobulin (beta 2M) is required for their normal expression. Mouse chimeras derived from embryonic stem cells with a disrupted beta 2M gene transmitted the inactivated gene to their progeny. Animals homozygous for the mutated beta 2M gene were...

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Identifiers

PMID: 2112266
DOI: 10.1126/science.2112266

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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