Article
Distinct sequence of negative or positive selection implied by thymocyte T-cell receptor densities.
Nature - 30 Aug 1990
Ohashi P S, Pircher H, Bürki K, Zinkernagel R M, Hengartner H
Abstract excerpt
Recent evidence suggests that positive and negative selection of thymocytes bearing alpha beta T-cell receptors occurs during the predominant double-positive (CD4+CD8+) stage. But the sequence or stage at which positive or negative selection occurs during thymocyte maturation has not been well defined. Here we use transgenic mice to show that the CD4+CD8+ stage might be further subdivided into CD3lo (low) and...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.