Article
Distinct sequence of negative or positive selection implied by thymocyte T-cell receptor densities.
Nature - 30 Aug 1990
Ohashi P S, Pircher H, Bürki K, Zinkernagel R M, Hengartner H
Abstract excerpt
Recent evidence suggests that positive and negative selection of thymocytes bearing alpha beta T-cell receptors occurs during the predominant double-positive (CD4+CD8+) stage. But the sequence or stage at which positive or negative selection occurs during thymocyte maturation has not been well defined. Here we use transgenic mice to show that the CD4+CD8+ stage might be further subdivided into CD3lo (low) and...
Topics
- Animals
- Antibodies, Monoclonal
- Antigens, CD
- Antigens, Differentiation, T-Lymphocyte
- CD3 Complex
- CD4-Positive T-Lymphocytes
- H-2 Antigens
- Haplotypes
- Immune Tolerance
- Lymphocytic choriomeningitis virus
- Mice