Article
Disruption of hypothalamic-pituitary-adrenocortical system in transgenic mice expressing type II glucocorticoid receptor antisense ribonucleic acid permanently impairs T cell function: effects on T cell trafficking and T cell responsiveness during postnatal development.
Endocrinology - 1 Sept 1995
Morale M C, Batticane N, Gallo F, Barden N, Marchetti B
Abstract excerpt
We used transgenic mice with impaired corticosteroid receptor function, caused by expression of type II glucocorticoid receptor (GR) antisense RNA, to study the role of glucocorticoid feedback during the developmental maturation of hypothalamus-pituitary-adrenal-immune functions. These mice have increased plasma concentrations of ACTH and corticosterone as well as reduced GR binding capacity. In control mice, a...
Topics
- Adrenocorticotropic Hormone
- Animals
- B-Lymphocyte Subsets
- CD4 Antigens
- CD8 Antigens
- Cell Count
- Cell Division
- Cells, Cultured
- Corticosterone
- Dexamethasone