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Article

Negative selection of thymocytes expressing the D10 TCR.

Proceedings of the National Academy of Sciences of the United States of America - 14 May 2002

Sant'Angelo Derek B, Janeway Charles A

Abstract excerpt

We have analyzed the patterns of positive and negative selection of thymocytes expressing the T cell antigen receptor (TCR) from the D10.G4.1 T cell clone. This TCR confers reactivity to several non-self MHC class II alleles with a remarkably broad range of avidities. Therefore, negative selection can be studied when induced by high-, intermediate-, or low-avidity interactions with endogenous peptide-MHC...

Topics

Alleles
Animals
CD4-Positive T-Lymphocytes
Gene Expression
Histocompatibility Antigens Class II
Mice
Mice, Transgenic
Receptors, Antigen, T-Cell, alpha-beta
T-Lymphocytes
Thymus Gland

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 12011450
DOI: 10.1073/pnas.102182499
PMCID: PMC124506

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Negative selection of thymocytes expressing the D10 TCR.PMID 12011450Read ↗

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