Article
TP53 gene mutations and CCND1 gene amplification in head and neck squamous cell carcinoma cell lines.
International journal of cancer - 1 Nov 1994
Xu L, Davidson B J, Murty V V, Li R G, Sacks P G, Garin-Chesa P, Schantz S P, Chaganti R S
Abstract excerpt
Mutations of the tumor-suppressor gene TP53 and amplification of CCND1 gene have been reported to occur frequently in head and neck squamous cell carcinomas (HNSQCC). In experimental systems, TP53 mutations have been shown to lead to genomic instability, including an increased propensity for gene...
Topics
- Carcinoma, Squamous Cell
- Cyclin D1
- Cyclins
- DNA, Neoplasm
- Gene Amplification
- Gene Expression
- Genes, p53
- Head and Neck Neoplasms
- Humans
- Immunoblotting
- Immunoenzyme Techniques
- Molecular Probe Techniques
- Mutation
- Oncogene Proteins
- Tumor Cells, Cultured
- Tumor Suppressor Protein p53