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Article

TP53 gene mutations and CCND1 gene amplification in head and neck squamous cell carcinoma cell lines.

International journal of cancer - 1 Nov 1994

Xu L, Davidson B J, Murty V V, Li R G, Sacks P G, Garin-Chesa P, Schantz S P, Chaganti R S

Abstract excerpt

Mutations of the tumor-suppressor gene TP53 and amplification of CCND1 gene have been reported to occur frequently in head and neck squamous cell carcinomas (HNSQCC). In experimental systems, TP53 mutations have been shown to lead to genomic instability, including an increased propensity for gene amplification. We have examined 16 HNSQCC cell lines for the association between TP53 over-expression/mutation and...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 7927946
DOI: 10.1002/ijc.2910590316

Genes

CCND1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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