Article
Sequential p53 mutation analysis of pre-invasive and invasive head and neck squamous carcinoma.
International journal of cancer - 22 Jun 1995
el-Naggar A K, Lai S, Luna M A, Zhou X D, Weber R S, Goepfert H, Batsakis J G
Abstract excerpt
Single-stranded conformational polymorphism (SSCP) and direct sequencing were performed on uninvolved mucosa, severe dysplasia and invasive carcinoma samples from 20 patients with head and neck squamous carcinoma. Seven (35%) of the non-invasive lesions and 15 (75%) of the invasive carcinomas manifested p53 mutations. Although the majority of mutations were mis-sense, resulting in single amino acid substitution,...
Topics
- Adult
- Aged
- Base Sequence
- Carcinoma, Squamous Cell
- Female
- Genes, p53
- Head and Neck Neoplasms
- Humans
- Male
- Middle Aged
- Molecular Sequence Data
- Mutation