Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Loss of heterozygosity on chromosome arm 17p in small cell lung carcinomas, but not in neurofibromas, in a patient with von Recklinghausen neurofibromatosis.

Cancer - 1 Feb 1993

Shimizu E, Shinohara T, Mori N, Yokota J, Tani K, Izumi K, Obashi A, Ogura T

Abstract excerpt

BACKGROUND: It has been suggested that the genetic abnormality responsible for von Recklinghausen neurofibromatosis (NF1) increases a patient's risk of various kinds of malignancies. The incidence of small cell lung carcinoma (SCLC) as a complication of NF1, however, is rare. To clarify the relationship between NF1 and SCLC, possible loss of heterozygosity of chromosome 17 in a patient with SCLC combined with NF1...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Alleles
Share to Chromosome Deletion

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Chromosome Mapping

Share to Chromosomes, Human, Pair 17

Share to Heterozygote

Share to Lung Neoplasms

Share to Polymorphism, Restriction Fragment Length

Share to Sensitivity and Specificity

Source

Identifiers

PMID: 8094318
DOI: 10.1002/1097-0142(19930201)71:3<725::aid-cncr2820710312>3.0.co;2-f

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Loss of heterozygosity on chromosome arm 17p in small cell lung carcinomas, but not in neurofibromas, in a patient with von Recklinghausen neurofibromatosis.PMID 8094318Read ↗

Loss of heterozygosity frequently affects chromosome 17q in non-small cell lung cancer.Semantic proximity Read ↗

Chromosome 17p deletions and p53 gene mutations associated with the formation of malignant neurofibrosarcomas in von Recklinghausen neurofibromatosis.Semantic proximity Read ↗

Molecular and cytogenetic analysis of tumors in von Recklinghausen neurofibromatosis.Semantic proximity Read ↗

Loss of heterozygosity on the short arm of chromosome 17 in human astrocytomas.Semantic proximity Read ↗

Pediatric brain tumors: loss of heterozygosity at 17p and TP53 gene mutations.Semantic proximity Read ↗

Detailed deletion mapping suggests the involvement of a tumor suppressor gene at 17p13.3, distal to p53, in the pathogenesis of lung cancers.Semantic proximity Read ↗

Genetic alterations in a malignant schwannoma from a patient with neurofibromatosis (NF1).Semantic proximity Read ↗

Somatic TP53 mutations are relatively rare among adrenocortical cancers with the frequent 17p13 loss of heterozygosity.Semantic proximity Read ↗

Loss of heterozygosity on 6q, 16q, and 17p in human central nervous system primitive neuroectodermal tumors.Semantic proximity Read ↗

A detailed study of loss of heterozygosity on chromosome 17 in tumours from Li-Fraumeni patients carrying a mutation to the TP53 gene.Semantic proximity Read ↗

Loss of heterozygosity on chromosome 10, 13q(Rb), 17p, and p53 gene mutations in human brain gliomas.Semantic proximity Read ↗

Loss of neurofibromin in adrenal gland tumors from patients with neurofibromatosis type ISemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.