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Article

Loss of heterozygosity on chromosome arm 17p in small cell lung carcinomas, but not in neurofibromas, in a patient with von Recklinghausen neurofibromatosis.

Cancer - 1 Feb 1993

Shimizu E, Shinohara T, Mori N, Yokota J, Tani K, Izumi K, Obashi A, Ogura T

Abstract excerpt

BACKGROUND: It has been suggested that the genetic abnormality responsible for von Recklinghausen neurofibromatosis (NF1) increases a patient's risk of various kinds of malignancies. The incidence of small cell lung carcinoma (SCLC) as a complication of NF1, however, is rare. To clarify the relationship between NF1 and SCLC, possible loss of heterozygosity of chromosome 17 in a patient with SCLC combined with NF1...

Topics

Alleles
Carcinoma, Small Cell
Chromosome Deletion
Chromosome Mapping
Chromosomes, Human, Pair 17
Female
Heterozygote
Humans
Lung Neoplasms
Middle Aged
Neurofibromatosis 1

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Polymorphism, Restriction Fragment Length

Sensitivity and Specificity

Source

Identifiers

PMID: 8094318
DOI: 10.1002/1097-0142(19930201)71:3<725::aid-cncr2820710312>3.0.co;2-f

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-8094318-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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Loss of heterozygosity on chromosome arm 17p in small cell lung carcinomas, but not in neurofibromas, in a patient with von Recklinghausen neurofibromatosis.PMID 8094318Read ↗

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