Article
Detailed deletion mapping suggests the involvement of a tumor suppressor gene at 17p13.3, distal to p53, in the pathogenesis of lung cancers.
Oncogene - 22 Oct 1998
Konishi H, Takahashi T, Kozaki K, Yatabe Y, Mitsudomi T, Fujii Y, Sugiura T, Matsuda H, Takahashi T, Takahashi T
Abstract excerpt
The short arm of chromosome 17 is one of the most frequently affected chromosomal regions in lung cancers, while there is solid evidence that the p53 gene at 17p13.1 is a target for frequent 17p deletions. In the present study, we re-evaluated 17p deletions in lung cancers by conducting a detaile...
Topics
- Adenocarcinoma
- Carcinoma, Large Cell
- Carcinoma, Small Cell
- Carcinoma, Squamous Cell
- Chromosome Mapping
- Chromosomes, Human, Pair 17
- Genes, p53
- Humans
- Loss of Heterozygosity
- Lung Neoplasms
- Mutation
- Sequence Deletion