A detailed study of loss of heterozygosity on chromosome 17 in tumours from Li-Fraumeni patients carrying a mutation to the TP53 gene.

doi:10.1038/sj.onc.1201041

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Article

A detailed study of loss of heterozygosity on chromosome 17 in tumours from Li-Fraumeni patients carrying a mutation to the TP53 gene.

Oncogene - 20 Feb 1997

Varley J M, Thorncroft M, McGown G, Appleby J, Kelsey A M, Tricker K J, Evans D G, Birch J M

Abstract excerpt

We have studied a total of 36 tumours from 28 patients with germline mutations to the TP53 gene for loss of heterozygosity at TP53 using techniques of both direct sequencing and restriction fragment length polymorphism analysis. All patients were from families conforming to the definition of clas...

Topics

Chromosome Deletion
Chromosomes, Human, Pair 17
Genes, p53
Humans
Li-Fraumeni Syndrome
Mutation
Neoplasms

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