Article
Genetic alterations in a malignant schwannoma from a patient with neurofibromatosis (NF1).
Pathology, research and practice - 1 May 1993
Lothe R A, Saeter G, Danielsen H E, Stenwig A E, Høyheim B, O'Connell P, Børresen A L
Abstract excerpt
In a patient with neurofibromatosis (von Recklinghausen disease; NF1), normal lymphocytes, five cutaneous neurofibromas, and tumour tissue from a recurrence of a malignant schwannoma were analysed for genetic alterations. Eleven DNA markers located on chromosome 17 and nine randomly chosen marker...
Topics
- Adult
- Alleles
- Chromosome Mapping
- DNA
- DNA Probes
- Densitometry
- Gene Deletion
- Genetic Markers
- Homozygote
- Humans
- Male
- Neoplasms, Multiple Primary
- Neurilemmoma
- Neurofibromatosis 1
- Polymorphism, Genetic
- Skin Neoplasms