Article
Regulation of initial vinblastine influx by P-glycoprotein.
British journal of cancer - 1 Jan 1993
Shalinsky D R, Jekunen A P, Alcaraz J E, Christen R D, Kim S, Khatibi S, Howell S B
Abstract excerpt
P-glycoprotein (PGP) is an energy-dependent efflux pump that serves to protect cells against the cytotoxicity of many natural product drugs including vinblastine (VBL). In this study we investigated the role of PGP in regulating initial VBL influx. The apparent influx of VBL, measured over the first 20 s, was 2-fold lower in KB-GRC1 cells expressing a transfected mdr1 gene at high level than in non-expressing...
Topics
- ATP Binding Cassette Transporter, Subfamily B, Member 1
- Adenosine Triphosphate
- Animals
- Binding Sites
- Cell Membrane
- Dipyridamole
- Drug Resistance
- Humans
- KB Cells
- Membrane Glycoproteins
- Mice