Article
Transport of phosphatidylcholine in MDR3-negative epithelial cell lines via drug-induced MDR1 P-glycoprotein.
Biochemical and biophysical research communications - 19 Aug 1999
Abulrob A G, Gumbleton M
Abstract excerpt
Human MDR1 P-glycoprotein (P-gp) is a membrane efflux pump for cytotoxics, whereas MDR3 P-gp is a phosphatidylcholine transporter. We have examined a role for MDR1 P-gp in phosphatidylcholine transport in MDR3-negative epithelial cells that have been induced to express the MDR1 P-gp by exposure to cytotoxics. The accumulation and retention of the fluorescently labelled phosphatidylcholine analogue, C12-NBD-PC,...
Topics
- 4-Chloro-7-nitrobenzofurazan
- ATP Binding Cassette Transporter, Subfamily B
- ATP Binding Cassette Transporter, Subfamily B, Member 1
- ATP-Binding Cassette Transporters
- Biological Transport
- Doxorubicin
- Drug Resistance, Neoplasm
- Epithelial Cells
- Flow Cytometry