Article
Multidrug resistance in MCF-7 human breast cancer cells is associated with increased expression of nucleoside transporters and altered uptake of adenosine.
Cancer chemotherapy and pharmacology - 1 Jan 1991
Morgan P F, Fine R L, Montgomery P, Marangos P J
Abstract excerpt
The rate of adenosine uptake and the corresponding expression of nucleoside transporters were studied in several MCF-7 human breast-cancer cell lines that express different levels of multidrug resistance (MDR). Kinetic studies of adenosine transport in these cell lines revealed that the mean apparent Km and Vmax values for the nucleoside transporters increased with increasing MDR. The apparent Km and the apparent...
Topics
- Adenosine
- Breast Neoplasms
- Carrier Proteins
- Doxorubicin
- Drug Resistance
- Humans
- Membrane Proteins
- Nucleoside Transport Proteins
- Phenotype
- Protein Kinase C
- Tumor Cells, Cultured