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Article

Vincristine cellular pharmacokinetic changes associated with multidrug resistance.

European journal of pharmacology - 1 Jun 1993

Domènech C, Fierro-Durán G, Rodríguez L, Grau-Oliete M R, Rivera-Fillat M P

Abstract excerpt

The correlation between vincristine cellular pharmacokinetics and its biological action was analyzed in L5178Y cells and in a multidrug resistant subline (VCR/G40) at the nM drug concentration range attained in serum during the clinical use of the drug. The reduced rate of drug influx and the higher drug efflux measured in VCR/G40 cells justify the lower drug accumulation characterized in these cells compared to...

Topics

ATP Binding Cassette Transporter, Subfamily B, Member 1
Animals
Antineoplastic Agents
Blotting, Western
Carrier Proteins
Drug Resistance
Membrane Glycoproteins
Mice
Phenotype
Tumor Cells, Cultured

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Vincristine

Source

Identifiers

PMID: 8101818
DOI: 10.1016/0926-6917(93)90024-k

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-8101818-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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