Article
Effect of extracellular ATP on the human leukaemic cell line K562 and its multidrug counterpart.
Molecular and cellular biochemistry - 1 Sept 2006
Bernardo Alcira A, Pinto-Silva Flavio Eduardo, Persechini Pedro M, Coutinho-Silva Robson, Meyer-Fernandes José Roberto, de Souza André Luiz Fonseca, Rumjanek Vivian M
Abstract excerpt
Extracellular ATP (ATPo) is capable of inducing different events on cells through receptor activation. The effect produced by ATPo was studied in the cell line K562 and its multidrug resistant (MDR) counterpart, Lucena 1. Lower ATPo concentrations (1 mM and 2.5 mM) led to high (3)H-thymidine incorporation but no increase in cell number. Similarly, the cell cycle profile indicated an increase of cells in S phase...
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