Article
A phase I trial of intrahepatic verapamil and doxorubicin. Regional therapy to overcome multidrug resistance.
Cancer - 15 Nov 1994
Saltz L, Murphy B, Kemeny N, Bertino J, Tong W, Keefe D, Tzy-Jun Y, Tao Y, Kelsen D, O'Brien J P
Abstract excerpt
BACKGROUND: Verapamil can modulate multidrug resistance in vitro, but only at levels that are not tolerable when administered systemically. Regional strategies of drug administration may permit the delivery of high concentrations of a drug to specific areas with lower systemic levels. Colorectal cancers typically express the multidrug resistance phenotype. METHODS: A Phase I trial was performed to determine the...
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