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Article

Pervilleine A, a novel tropane alkaloid that reverses the multidrug-resistance phenotype.

Cancer research - 15 May 2001

Mi Q, Cui B, Silva G L, Lantvit D, Lim E, Chai H, You M, Hollingshead M G, Mayo J G, Kinghorn A D, Pezzuto J M

Abstract excerpt

P-Glycoprotein-mediated drug efflux can yield a multidrug-resistance (MDR) phenotype that is associated with a poor response to cancer chemotherapy. Pervilleine A, a novel tropane alkaloid obtained from a chloroform extract of Erythroxylum pervillei as the result of bioactivity-guided fractionation, was found to restore the vinblastine sensitivity of cultured multidrug-resistant KB-V1 and CEM/VLB(100) cells, with...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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PMID: 11358822

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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