Article
Pervilleine A, a novel tropane alkaloid that reverses the multidrug-resistance phenotype.
Cancer research - 15 May 2001
Mi Q, Cui B, Silva G L, Lantvit D, Lim E, Chai H, You M, Hollingshead M G, Mayo J G, Kinghorn A D, Pezzuto J M
Abstract excerpt
P-Glycoprotein-mediated drug efflux can yield a multidrug-resistance (MDR) phenotype that is associated with a poor response to cancer chemotherapy. Pervilleine A, a novel tropane alkaloid obtained from a chloroform extract of Erythroxylum pervillei as the result of bioactivity-guided fractionation, was found to restore the vinblastine sensitivity of cultured multidrug-resistant KB-V1 and CEM/VLB(100) cells, with...
Topics
- ATP Binding Cassette Transporter, Subfamily B, Member 1
- Antineoplastic Agents, Phytogenic
- Blotting, Western
- Cell Division
- Colchicine
- Drug Resistance, Multiple
- Drug Screening Assays, Antitumor
- Genes, MDR
- Humans
- Inhibitory Concentration 50
- KB Cells
- Phenotype