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Article

Differences in the expression of endogenous efflux transporters inMDR1‐transfected versus wildtype cell lines affect P‐glycoprotein mediated drug transport

14 Apr 2010

Abstract excerpt

BACKGROUND AND PURPOSE: P-glycoprotein (Pgp) efflux assays are widely used to identify Pgp substrates. The kidney cell lines Madin-Darby canine kidney (MDCK)-II and LLC-PK1, transfected with human MDR1 (ABCB1) are used to provide recombinant models of drug transport. Endogenous transporters in these cells may contribute to the activities of recombinant transporters, so that drug transport in MDR1-transfected...

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PMID: 20590635
DOI: 10.1111/j.1476-5381.2010.00801.x

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