Article
Energy-dependent processes involved in reduced drug accumulation in multidrug-resistant human lung cancer cell lines without P-glycoprotein expression.
Cancer research - 1 Jan 1992
Versantvoort C H, Broxterman H J, Pinedo H M, de Vries E G, Feller N, Kuiper C M, Lankelma J
Abstract excerpt
Mechanisms contributing to reduced cytotoxic drug accumulation were studied in two multidrug-resistant (MDR) human lung cancer cell lines without P-glycoprotein expression. In these (non-small cell) SW-1573/2R120 and (small cell) GLC4/ADR MDR cells, the steady-state accumulation of [14C]daunorubi...
Topics
- Adenosine Triphosphate
- Carcinoma, Non-Small-Cell Lung
- Cell Membrane Permeability
- Daunorubicin
- Drug Resistance
- Energy Metabolism
- Etoposide
- Gene Expression Regulation, Neoplastic
- Humans
- Hydrogen-Ion Concentration
- Lung Neoplasms
- Nigericin
- Phenotype
- RNA, Messenger
- Tumor Cells, Cultured
- Vincristine