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Article

Induction of Multidrug Resistance in Human Cells by Transient Exposure to Different Chemotherapeutic Drugs

21 Apr 1993

Abstract excerpt

BACKGROUND: The MDR1 (multidrug resistance) gene (also known as PGY1), which encodes the transmembrane efflux pump P-glycoprotein (Pgp), confers resistance to Pgp-transported cytotoxic drugs in tissue culture. The increase in MDR1 expression in tumors after chemotherapy is usually attributed to selection of pre-existing multidrug-resistant cells by Pgp-transported drugs. MDR1 expression in tissue culture can be...

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PMID: 8096875
DOI: 10.1093/jnci/85.8.632

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