Article
A novel gene encoding a B-box protein within the BRCA1 region at 17q21.1.
Human molecular genetics - 1 Apr 1994
Campbell I G, Nicolai H M, Foulkes W D, Senger G, Stamp G W, Allan G, Boyer C, Jones K, Bast R C, Solomon E
Abstract excerpt
A novel cDNA clone was isolated using a polyclonal serum directed against partially purified ovarian carcinoma antigen CA125. The deduced peptide sequence lacked membrane protein characteristics expected for CA125 but encompassed a B-box/coiled coil motif present in many genes with transformation...
Topics
- Amino Acid Sequence
- Antigens, Tumor-Associated, Carbohydrate
- Base Sequence
- Breast Neoplasms
- Chromosome Mapping
- Chromosomes, Human, Pair 17
- DNA Mutational Analysis
- DNA, Complementary
- DNA, Neoplasm
- Exons
- Female
- Genes
- Genetic Markers
- Genetic Predisposition to Disease
- Humans