Article
A nuclear function for the tumor suppressor BRCA1.
Histology and histopathology - 1 Jan 2000
Monteiro A N, Birge R B
Abstract excerpt
The breast and ovarian cancer susceptibility gene BRCA1 has been recently cloned and revealed an open reading frame of 1863 amino acids, but a lack of significant homology to any known protein in the database has led to few clues about its functions. One of the first steps to investigate the function of BRCA1 was to define its subcellular localization. Several reports have led to contradictory findings that...
Topics
- BRCA1 Protein
- Breast Neoplasms
- Cell Nucleus
- Female
- Genes, BRCA1
- Humans
- Mutation
- Ovarian Neoplasms