Mutations of the BRCA1 gene in human cancer.

doi:10.1006/scbi.1996.0005

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Article

Mutations of the BRCA1 gene in human cancer.

Seminars in cancer biology - 1 Feb 1996

Xu C F, Solomon E

Abstract excerpt

BRCA1 is a putative tumour suppressor gene located on chromosome 17q21. It spans 100kb of genomic DNA and encodes a protein of 200kD consisting of 1863 amino acids. Sixty-three distinct germline mutations of BRCA1 have now been identified in more than 100 patients with breast and/or ovarian cance...

Topics

BRCA1 Protein
Base Sequence
Breast Neoplasms
Female
Genes, Tumor Suppressor
Humans
Molecular Sequence Data
Mutation
Neoplasm Proteins
Ovarian Neoplasms
Transcription Factors

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