Article
Complete genomic sequence and analysis of 117 kb of human DNA containing the gene BRCA1.
Genome research - 1 Nov 1996
Smith T M, Lee M K, Szabo C I, Jerome N, McEuen M, Taylor M, Hood L, King M C
Abstract excerpt
Over 100 distinct disease-associated mutations have been identified in the breast-ovarian cancer susceptibility gene BRCA1. Loss of the wild-type allele in > 90% of tumors from patients with inherited BRCA1 mutations indicates tumor suppressive function. The low incidence of somatic mutations suggests that BRCA1 inactivation in sporadic tumors occurs by alternative mechanisms, such as interstitial chromosomal...
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