Article
A 400 kb novel deletion unit centromeric to the BRCA1 gene in sporadic epithelial ovarian cancer.
Oncogene - 15 Feb 1996
Tangir J, Muto M G, Berkowitz R S, Welch W R, Bell D A, Mok S C
Abstract excerpt
Allelic deletions on chromosome 17q21 in sporadic ovarian cancer are common, suggesting that inactivation of a tumor suppressor gene(s) in that region may be important for the etiology of these tumors. The recently identified BRCA1 gene on 17q21, involved in the development of familial breast/ova...
Topics
- Alleles
- BRCA1 Protein
- Breast Neoplasms
- Centromere
- Chromosome Deletion
- Chromosome Mapping
- Chromosomes, Human, Pair 17
- DNA, Neoplasm
- Female
- Gene Deletion
- Genes, Tumor Suppressor
- Genetic Markers
- Humans
- Neoplasm Proteins
- Ovarian Neoplasms
- Polymerase Chain Reaction
- Polymorphism, Genetic
- Repetitive Sequences, Nucleic Acid