Mutational analysis of theBRCA1-interacting genesZNF350/ZBRK1andBRIP1/BACH1amongBRCA1andBRCA2-negative probands from breast-ovarian cancer families and among early-onset breast cancer cases and reference individuals

Abstract excerpt

Two potential breast cancer susceptibility genes, encoding the BRCA1-interacting proteins ZNF350 (or ZBRK1) and BRIP1 (or BACH1), have been identified in yeast two-hybrid screens. We sequenced these genes in probands from 21 families with potentially inherited breast/ovarian cancer, all of which were negative for BRCA1/BRCA2 mutations. Families had at least one case of male breast cancer, two cases of ovarian...

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