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Article

Cloning and genomic organization of beclin 1, a candidate tumor suppressor gene on chromosome 17q21.

Genomics - 1 Jul 1999

Aita V M, Liang X H, Murty V V, Pincus D L, Yu W, Cayanis E, Kalachikov S, Gilliam T C, Levine B

Abstract excerpt

The beclin 1 (BECN1) gene encodes a 60-kDa coiled-coil protein that interacts with the prototypic apoptosis inhibitor Bcl-2. Previous studies indicate that beclin 1 maps to a region approximately 150 kb centromeric to BRCA1 on chromosome 17q21 that is commonly deleted in breast, ovarian, and prostate cancer. The complete cDNA sequence of beclin 1 encodes a 2098-bp transcript, with a 120-bp 5' UTR, 1353-bp coding...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Chromosomes, Human, Pair 17

Share to DNA, Complementary

Share to Genes, Tumor Suppressor

Share to In Situ Hybridization, Fluorescence

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Source

Identifiers

PMID: 10395800
DOI: 10.1006/geno.1999.5851

Genes

BECN1
BRCA1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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