Article
A strong candidate for the breast and ovarian cancer susceptibility gene BRCA1.
Science (New York, N.Y.) - 7 Oct 1994
Miki Y, Swensen J, Shattuck-Eidens D, Futreal P A, Harshman K, Tavtigian S, Liu Q, Cochran C, Bennett L M, Ding W
Abstract excerpt
A strong candidate for the 17q-linked BRCA1 gene, which influences susceptibility to breast and ovarian cancer, has been identified by positional cloning methods. Probable predisposing mutations have been detected in five of eight kindreds presumed to segregate BRCA1 susceptibility alleles. The m...
Topics
- Alleles
- Alternative Splicing
- Amino Acid Sequence
- Animals
- BRCA1 Protein
- Breast Neoplasms
- Chromosomes, Human, Pair 17
- Female
- Genes, Tumor Suppressor
- Genetic Predisposition to Disease
- Germ-Line Mutation
- Haplotypes
- Humans
- Lod Score
- Male
- Molecular Sequence Data
- Mutation
- Neoplasm Proteins