Physical mapping, cloning, and identification of genes within a 500-kb region containing BRCA1.

doi:10.1073/pnas.92.10.4362

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Article

Physical mapping, cloning, and identification of genes within a 500-kb region containing BRCA1.

Proceedings of the National Academy of Sciences of the United States of America - 9 May 1995

Brown M A, Jones K A, Nicolai H, Bonjardim M, Black D, McFarlane R, de Jong P, Quirk J P, Lehrach H, Solomon E

Abstract excerpt

BRCA1 is a breast/ovarian cancer susceptibility gene on human chromosome 17q21. We describe a complete and detailed physical map of a 500-kb region of genomic DNA containing the BRCA1 gene and the partial cloning in phage P1 artificial chromosomes. Approximately 70 exons were isolated from this region, 11 of which were components of the BRCA1 gene. Analysis of the other exons revealed a rho-related G protein and...

Topics

Amino Acid Sequence
BRCA1 Protein
Breast Neoplasms
Chromosome Mapping
Chromosomes, Human, Pair 17
Cloning, Molecular
Cosmids
Exons
Female
Genetic Predisposition to Disease

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Humans

Molecular Sequence Data

Neoplasm Proteins

Ovarian Neoplasms

Restriction Mapping

Sequence Homology, Amino Acid

Transcription Factors

Transcription, Genetic

Source

Open in PubMed Open full text

Identifiers

PMID: 7753812
DOI: 10.1073/pnas.92.10.4362
PMCID: PMC41944

Genes

BRCA1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-7753812-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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