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Article

Activation of the K-ras gene by insertion mutations in chemically induced rat renal mesenchymal tumors.

Oncogene - 1 Sept 1994

Higinbotham K G, Rice J M, Buzard G S, Perantoni A O

Abstract excerpt

Previously we reported the detection of transforming K-ras sequences in methyl(methoxymethyl)nitrosamine (DMN-OMe)-induced rat renal mesenchymal tumors by NIH3T3 transfection assays. Subsequent analysis by selective oligonucleotide hybridization revealed a variety of activating point mutations in codon 12 of K-ras in most of these tumors and in their NIH3T3 transformants, but in some, point mutations could not be...

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PMID: 8058308

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