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Article

Activating point mutation in Ki-ras codon 63 in a chemically induced rat renal tumor.

Molecular carcinogenesis - 1 Jan 1992

Higinbotham K G, Rice J M, Perantoni A O

Abstract excerpt

Renal mesenchymal tumors induced in F344 rats with methyl(methoxymethyl)nitrosamine (DMN-OMe) have previously been shown by our laboratory to contain transforming Ki-ras sequences, activated most commonly by a variety of codon 12 mutations. Further sequence analysis of the one DMN-OMe-induced tumor with transforming Ki-ras sequences detected by NIH 3T3 transfection assay but with no mutation in codon 12 detected...

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Identifiers

PMID: 1554412
DOI: 10.1002/mc.2940050209

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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