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Article

Activating point mutation in Ki-ras codon 63 in a chemically induced rat renal tumor.

Molecular carcinogenesis - 1 Jan 1992

Higinbotham K G, Rice J M, Perantoni A O

Abstract excerpt

Renal mesenchymal tumors induced in F344 rats with methyl(methoxymethyl)nitrosamine (DMN-OMe) have previously been shown by our laboratory to contain transforming Ki-ras sequences, activated most commonly by a variety of codon 12 mutations. Further sequence analysis of the one DMN-OMe-induced tumor with transforming Ki-ras sequences detected by NIH 3T3 transfection assay but with no mutation in codon 12 detected...

Topics

3T3 Cells
Animals
Base Sequence
Carcinogens
Codon
Dimethylnitrosamine
Exons
Gene Expression Regulation, Neoplastic
Genes, ras
Kidney Neoplasms
Mice
Molecular Sequence Data

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Mutation

Rats

Rats, Inbred F344

Source

Identifiers

PMID: 1554412
DOI: 10.1002/mc.2940050209

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-1554412-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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