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Article

Absence of H-ras point mutation at codon 12 in N-methyl-N-nitrosourea-induced hepatocellular neoplasms in the rat.

Journal of cancer research and clinical oncology - 1 Jan 1990

Li H, Lee G H, Cui L X, Liu J, Nomura K, Ohtake K, Kitagawa T

Abstract excerpt

In order to assess the possibility that activated ras-associated hepatic carcinomas might be much rarer in rats than mice because of the more frequent or rapid occurrence of powerful carcinogenic event(s) other than ras point mutations in the former animals, precancerous lesions and hepatocellular carcinomas induced by a weak hepatocarcinogen N-methyl-N-nitrosourea (MNU) in the rat liver were analyzed for the...

Topics

Animals
Codon
Genes, ras
Glutathione Transferase
Liver
Liver Neoplasms, Experimental
Methylnitrosourea
Mutation
Polymorphism, Restriction Fragment Length
RNA, Messenger
Rats

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Rats, Inbred F344

Time Factors

Transfection

Source

Identifiers

PMID: 1975252
DOI: 10.1007/BF01612914

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-1975252-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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Absence of H-ras point mutation at codon 12 in N-methyl-N-nitrosourea-induced hepatocellular neoplasms in the rat.PMID 1975252Read ↗

Carcinogen-induced liver tumours of Wistar rats: absence of activated ras genes and of N-rasC.Semantic proximity Read ↗

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Ras gene mutation-independent tumours in the intestine of the rat by a single dose of N-methyl-N-nitrosourea.Semantic proximity Read ↗

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