Article
Variant mutational activation of the K-ras oncogene in renal mesenchymal tumors induced in newborn F344 rats by methyl(methoxymethyl)nitrosamine.
Carcinogenesis - 1 Dec 1996
Higinbotham K G, Rice J M, Reed C D, Watatani M, Enomoto T, Anderson L M, Perantoni A O
Abstract excerpt
Renal mesenchymal tumors were induced at high incidence in F344 rats by a single intraperitoneal injection of methyl(methoxymethyl)nitrosamine (DMN-OMe) within 48 h after birth. DNAs from 18 of 35 mesenchymal tumors contained transforming ras sequences in NIH3T3 transfection assays: K-ras (17/18)...
Topics
- Animals
- Female
- Gene Expression Regulation, Neoplastic
- Genes, ras
- Kidney Neoplasms
- Male
- Mutation
- Nitrosamines
- Polymorphism, Single-Stranded Conformational
- Rats
- Rats, Inbred F344